TABLE 1.

In vitro antibacterial activity of xeruborbactam against Enterobacterales, carbapenem-resistant Acinetobacter baumannii, and Pseudomonas aeruginosa

Organism(s) or resistance mechanism	No. of isolates	Value (μg/mL) for:		Range
		MIC50	MIC90
Enterobacterales	1,028	16	32	2 to 64
Klebsiella pneumoniae	575	16	32	4 to 64
Klebsiella pneumonia CREa	418	16	32	4 to 64
KPC	163	16	32	8 to 64
OXA-48-like	89	16	64	8 to 64
Non-carbapenemase producing	40	16	32	8 to 64
Metallo-beta-lactamase	126	16	32	8 to 32
Klebsiella pneumonia ESBL phenotypeb	157	16	16	4 to 32
Escherichia coli	334	8	16	2 to 32
Enterobacter cloacae species complex	45	16	32	4 to 64
Klebsiella oxytoca	23	8	16	8 to 32
Proteus mirabilis	23	16	32	8 to 16
Serratia marcescens	10	32	32	16 to 64
Othersc	18	16	32	8 to 64
Carbapenem-resistant Acinetobacter baumannii	505	16	64	1 to >64
Pseudomonas aeruginosa	506	>64	>64	8 to >64

^aCRE, carbapenem-resistant Enterobacteriaceae.

^bESBL phenotype was defined as a MIC of ≥1 μg/mL of either ceftazidime or aztreonam.

^cOther Enterobacterales included Citrobacter amalonaticus/farmeri (n = 1), Citrobacter freundii species complex (n = 7), Citrobacter koseri (n = 3), Enterobacter hormaechei (n = 2), Klebsiella aerogenes (n = 4), and Providencia stuartii (n = 1).