TABLE 10.

In vitro potency of xeruborbactam and vaborbactam to enhance the activity of meropenem against the clinical strains of KPC-producing K. pneumoniae according to the functional status of OmpK36

Strain, measure of potency	Meropenem MIC (μg/mL)					MIC (μg/mL) of:
	Alone	With vaborbactam at:		With xeruborbactam at:
		8 μg/mL	64 μg/mL	4 μg/mL	8 μg/mL	Vaborbactam	Xeruborbactam
All strains (n = 141)
MIC50	128	1	0.125	0.125	≤0.06	>64	>16
MIC90	256	16	1	1	0.25	>64	>16
Strains with
Functional OmpK36
MIC50	16	0.03	0.03	≤0.06	≤0.06	>64	16
MIC90	128	0.06	0.06	≤0.06	≤0.06	>64	>16
Nonfunctional OmpK36
MIC50	256	2	0.25	0.25	0.125	>64	>16
MIC90	256	16	2	2	0.5	>64	>16