TABLE 2.
In vitro activity of various BLIs against isogenic strains of Gram-negative bacteria
| Strain | Genotype (phenotype) | MIC (mg/L) of: |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Xeruborbactam | Avibactam | Nacubactam | Zidebactam | Durlobactam | Meropenem | Cefepime | Aztreonam | ||
| Escherichia coli strains | |||||||||
| ECM5497 | Wild type | 8 | 16 | 4 | 0.125 | 0.5 | 0.03 | 0.03 | 0.03 |
| ECM6001 | ΔacrB | 8 | 16 | 4 | 0.125 | 0.5 | 0.03 | 0.03 | 0.03 |
| ECM6502 | marR (AcrAB overexpression) | 8 | 8 | 2 | 0.5 | 0.25 | 0.06 | 0.125 | 0.25 |
| Klebsiella pneumoniae strains | |||||||||
| KPM1026a | Wild type | 16 | 16 | 8 | 0.25 | 0.5 | 0.03 | 0.03 | 0.03 |
| KPM1027 | ramR | 16 | 16 | 4 | 0.25 | 0.5 | 0.06 | 0.25 | 0.25 |
| KPM2600 | ΔompK35 | 16 | 16 | 8 | 0.25 | 0.5 | 0.06 | 0.25 | 0.125 |
| KPM2040 | ompK36_2040 | 16 | 256 | >64 | >64 | 4 | 0.125 | 0.125 | 0.06 |
| KPM2613 | ΔompK35 ompK36_2040 | 32 | 256 | >64 | >64 | 8 | 0.25 | 0.25 | 0.25 |
| KPM1171 | ramR ompK36_1171 | 64 | >256 | >64 | >64 | 32 | 2 | 2 | 0.5 |
| KPM2696 | ΔacrB | 16 | 16 | 2 | 0.25 | 0.25 | 0.03 | 0.03 | 0.03 |
| Pseudomonas aeruginosa strains | |||||||||
| PAM1020 | Wild type | 256 | >256 | 128 | 2 | 64 | 0.25 | 0.5 | 4 |
| PAM1032 | nalB (MexAB-OprM overexpression) | >256 | >256 | 128 | 4 | >256 | 1 | 4 | 16 |
| PAM1033 | nfxB (MexCD-OprJ overexpression) | 128 | 32 | 32 | 0.125 | 4 | 0.25 | 4 | 1 |
| PAM1034 | nfxC (MexEF-OprN overexpression) | 256 | >256 | 128 | 2 | 128 | 0.5 | 0.5 | 4 |
| PAM1106 | mexA::Tet | 16 | 128 | 128 | 2 | 8 | 0.06 | 0.25 | 0.125 |
| PAM1154 | oprM::Hg | 16 | 128 | 128 | 2 | 8 | 0.06 | 0.125 | 0.125 |
| Acinetobacter baumannii strains | |||||||||
| AB1007 | Wild type | 16 | >256 | >256 | >256 | 64 | 0.25 | 4 | 32 |
| ACM1027 | adeN (AdeIJK overexpression) | 32 | >256 | >256 | >256 | 128 | 1 | 8 | 64 |
| ACM1030 | adeS (AdeABC overexpression) | 16 | >256 | >256 | >256 | 64 | 0.5 | 32 | 16 |
| ACM1013 | ΔadeIJK | 4 | >256 | >256 | >256 | 32 | 0.125 | 4 | 1 |
| ACM1014 | ΔadeABC | 16 | >256 | >256 | >256 | 64 | 0.125 | 1 | 16 |
| ACM1015 | ΔadeIJK ΔadeABC | 4 | >256 | >256 | >256 | 16 | 0.06 | 0.25 | 1 |