TABLE 5.
Antibiotic susceptibility profile of mutants with increased xeruborbactam MICs
| Strain | Description | MIC (μg/mL) ofa: |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Xeruborbactam | Avibactam | Zidebactam | Durlobactam | Mecillinam | Meropenem | Cefepime | Aztreonam | ||
| KPM1026a | Parent | 16 | 16 | 0.25 | 0.25 | 0.25 | 0.03 | 0.03 | 0.06 |
| KPM3532 | TolQ::M189K | 32 | >64 | >64 | 8 | >64 | 0.06 | 0.06 | 0.06 |
| KPM3534 | TolQ::S31F | 32 | >64 | >64 | 16 | >64 | 0.06 | 0.125 | 0.125 |
| KPM4235 | TolQ::IP(183–1844)PR | 32 | >64 | >64 | 16 | >64 | 0.06 | 0.125 | ND |
| KPM4236 | TolQ::TAA at aa 103b | 32 | >64 | >64 | 16 | >64 | 0.06 | 0.125 | ND |
| KPM4238 | TolQ::S25F | 32 | >64 | >64 | 16 | >64 | 0.06 | 0.125 | ND |
| KPM4239 | TolQ::S28F | 32 | >64 | >64 | 16 | >64 | 0.06 | 0.125 | ND |
| KPM4240 | TolQ::S25Y | 32 | >64 | >64 | 16 | >64 | 0.06 | 0.125 | ND |
a
ND, not determined.
b
aa, amino acid.