TABLE 7.

Effects of mutations causing increased xeruborbactam MICs on enhancement of antibiotic potency by xeruborbactam through PBP inhibition

Antibiotic	MIC (μg/mL) (fold decrease compared to MIC of antibiotic alone)
	KPM1026a			KPM3532 (TolQ::M189K)			KPM3534 (TolQ::S31F)
	Alone	With xeruborbactam at:		Alone	With xeruborbactam at:		Alone	With xeruborbactam at:
		4 μg/mL	8 μg/mL		4 μg/mL	8 μg/mL		4 μg/mL	8 μg/mL
Meropenem	0.03	0.015 (2)	0.004 (8)	0.06	0.03 (2)	0.015 (4)	0.06	0.03 (2)	0.015 (4)
Cefepime	0.03	0.015 (2)	0.002 (16)	0.06	0.03 (2)	0.015 (4)	0.125	0.03 (4)	0.015 (8)
Aztreonam	0.06	0.015 (4)	0.004 (16)	0.06	0.06 (1)	0.06 (1)	0.125	0.03 (4)	0.03 (4)
Ceftibuten	0.06	0.015 (4)	0.008 (8)	0.125	0.06 (2)	0.06 (2)	0.125	0.06 (2)	0.03 (4)
Mecillinam	0.25	≤0.06	≤0.06	>64	0.5	0.5	>64	0.5	0.5
Zidebactam	0.25	≤0.06	≤0.06	>64	0.25	0.125	>64	0.25	0.125
Durlobactam	0.25	0.125	≤0.06	8	0.25	0.125	16	0.25	0.125
Xeruborbactam	16	NAa	NA	32	NA	NA	32	NA	NA

^aNA, not applicable.