TABLE 1.

Total antibody and antibody subtype levels at days 7, 21, and 28 after subcutaneous tetanus toxoid administration to mice treated with clarithromycin, doxycycline, ampicillin, or NS

Day postvaccination	Antibody subtype	Serum dilution	Antibody level (A492)
			Mean for group treated with:				SEM (pooled)	Critical value
			Clarithromycin (n = 10)	Doxycycline (n = 10)	Ampicillin (n = 10)	NS (n = 10)
7	Total	1:500	0.150	0.122	0.152	0.164	0.015	0.058
	IgM	1:100	0.417a	0.554	0.659	0.696a	0.065	0.247
	IgG1	1:50	0.265	0.216	0.186	0.173	0.048	0.182
	IgG2a	1:50	0.014	0.009	0.010	0.012	0.002	0.009
21	Total	1:5,000	0.484	0.486	0.480	0.472	0.044	0.168
	IgM	1:100	0.122	0.181	0.156	0.130	0.023	0.088
	IgG1	1:500	0.382	0.354	0.364	0.355	0.019	0.071
	IgG2a	1:50	0.020	0.040	0.032	0.023	0.007	0.027
28	Total	1:50,000	0.200	0.174	0.185	0.158	0.016	0.060
	IgM	1:100	0.191	0.207	0.196	0.151	0.024	0.091
	IgG1	1:5,000	0.286	0.217	0.235	0.243	0.025	0.096
	IgG2a	1:50	0.105	0.293	0.200	0.133	0.057	0.217

^aThe difference is statistically significant compared to the mean with the same superscript.