TABLE 3.

Total antibody and antibody subtype levels at days 7, 21, and 28 after intraperitoneal HBsAg vaccine administration to mice treated with clarithromycin, doxycycline, ampicillin, or NS

Day postvaccination	Antibody subtype	Serum dilution	Antibody level (A492)
			Mean for group treated with:				SEM (pooled)	Critical value
			Clarithromycin (n = 10)	Doxycycline (n = 10)	Ampicillin (n = 10)	NS (n = 10)
7	Total	1:100	0.203	0.212	0.200	0.193	0.016	0.060
	IgM	1:100	0.357a	0.103ab	0.201	0.322b	0.029	0.210
	IgG1	1:50	0.027	0.026	0.026	0.027	0.002	0.007
	IgG2a	1:50	0.022	0.020	0.020	0.021	0.002	0.008
21	Total	1:100	0.293	0.466	0.506	0.721	0.143	0.543
	IgM	1:100	0.382	0.598	0.502	0.560	0.064	0.245
	IgG1	1:50	0.049	0.069	0.123	0.222	0.060	0.229
	IgG2a	1:50	0.060	0.039	0.099	0.162	0.045	0.172
28	Total	1:1,000	0.440	0.631	0.789	0.785	0.106	0.405
	IgM	1:100	0.379cde	0.602c	0.565d	0.574e	0.041	0.158
	IgG1	1:50	0.335	0.710	1.056	1.130	0.222	0.845
	IgG2a	1:50	0.464	0.339	0.565	0.626	0.140	0.533

^a–e The difference is statistically significant compared to the mean with the same superscript.