TABLE 4.

Total antibody and antibody subtype levels at days 7 and 21 after intraperitoneal Ty21a-pBR322 administration to mice treated with clarithromycin, doxycycline, ampicillin, or NS

Day postvaccination	Antibody subtype	Serum dilution	Antibody level (A492)
			Mean for group treated with:				SEM (pooled)	Critical value
			Clarithromycin (n = 10)	Doxycycline (n = 10)	Ampicillin (n = 10)	NS (n = 10)
7	Total	1:25	0.096	0.100	0.132a	0.069a	0.110	0.043
	IgM	1:25	0.226b	0.232c	0.234d	0.122bcd	0.024	0.093
	IgG1	1:25	0.012	0.013	0.011	0.013	0.001	0.004
	IgG2a	1:25	0.010	0.010	0.020	0.010	0.004	0.016
21	Total	1:25	0.681	0.523e	0.973ef	0.302f	0.101	0.386
	IgM	1:25	0.482g	0.524h	0.472i	0.158ghi	0.043	0.162
	IgG1	1:25	0.017	0.015	0.012	0.012	0.002	0.007
	IgG2a	1:25	0.019	0.017	0.019	0.017	0.004	0.016

^a–i The difference is statistically significant compared to the mean with the same superscript.