TABLE 5.

Serum IL-10 levels after subcutaneous tetanus toxoid, subcutaneous pneumococcal polysaccharide vaccine, intraperitoneal HBsAg, or intraperitoneal Ty21a-pBR322 administration to mice treated with clarithromycin, doxycycline, ampicillin, or NS

Vaccine	Day postvaccination	Serum IL-10 level (pg/ml)
		Mean for group treated with:				SEM (pooled)	Critical value
		Clarithromycin (n = 10)	Doxycycline (n = 10)	Ampicillin (n = 10)	NS (n = 10)
Tetanus toxoid	7	18	23	21	17	9	33
	21	Undetectablea	Undetectable	Undetectable	Undetectable
	28	55	26	56	88	26	98
Pneumococcal polysaccharide	7	5	4	4	13	3	13
	21	137	32	63	27	44	167
	28	17	12	16	17	9	35
HBsAg	7	31	31	40	49	17	63
	21	15	35	35	40	15	58
	28	2	12	4	2	2	8
Ty21a	7	Undetectable	Undetectable	Undetectable	Undetectable
	21	Undetectable	Undetectable	Undetectable	Undetectable

^aUndetectable, no statistically significant difference between the serum IL-10 levels on that day and day −1.