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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Continuum (Minneap Minn). 2022 Jun 1;28(3):702–725. doi: 10.1212/CON.0000000000001105

FIGURE 3–1.

FIGURE 3–1

Imaging of the patient in CASE 3-1. Coronal T1-weighted (A) and axial fluid-attenuated inversion recovery (FLAIR) (B) MRI at age 58 show frontal more than parietal atrophy, but minimal hippocampal atrophy. Coronal T1-weighted (C) and axial FLAIR (D) MRI at age 62 show progression of the frontal and parietal atrophy and only minimal hippocampal atrophy. Fludeoxyglucose positron emission tomography (FDG-PET) (E) at age 58 shows marked hypometabolism in the frontal regions, with slightly less prominent hypometabolism in the temporal and parietal regions and the posterior cingulate region. The color bar and z score reference on the far left of the FDG-PET image reflects the degree of FDG hypometabolism, with blue reflecting z scores in the −1 to −2 range and red reflecting a z score of −6. Therefore, the regions with gray or black color reflect normal metabolism, blue color reflects slight to mild hypometabolism, and green to yellow to red color reflects moderate to very severe hypometabolism.