Fig 7. C3 and C3aR-deficiency do not dramatically alter mouse susceptibility to Hc infection.

A-B C3ar-/- mice (n≥10) and age-matched WT C57BL/6 mice (n≥10) were infected intranasally with varying doses of Hc yeast to initiate either a sub-lethal (A) or lethal (B) infection. D. C3-/- mice and age-matched WT mice were infected intranasally with a sub-lethal dose of Hc yeast. Susceptibility is illustrated by a Kaplan-Meier survival curve. ns = not significant, *p < 0.05 by logrank test. C,E. The indicated mice were infected with a sub-lethal dose of Hc. The fungal burden in lung and spleen homogenates was determined by enumeration of colony forming units (CFUs) at the indicated time points (n≥5). X-axis label for C is the same as that indicated for E.