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Ribociclib pharmacokinetic parameters summary in mice bearing mouse tumor #2416 (n = 7).
| Parameters [unit] | Mean estimates (SD) |
|---|---|
| Half-life (h) | 4.26 (0.737) |
| Unbound Plasma AUC0–24h (ng × h/mL) | 5,820 (926) |
| tECF AUC0–24h/unbound Plasma AUC0–24h | 0.162 (0.119) |
Abbreviations: AUC0–24h, area under concentration–time curve from time zero to 24 hours after dose; tECF, tumor extracellular fluid.
