Table 3.

The SNPs and candidate genes with pleiotropic effect in this study.

SNP name	Traits	Gene	Distance(kb)*	Gene full name	Gene function
BovineHD1400000287	MY, FP, PP	PLEC	Intron	Plectin	Related to the MY, FP, and PP traits in Chinese Holsteins (20).
BovineHD0500025853	FP, FY	PLEKHA5	Intron	Pleckstrin homology domain containing, family A member 5	Significantly associated with FP (21).
BovineHD1400011649	MY, PY	HNF4G	Intron	Hepatocyte nuclear factor 4 gamma	Associated with childhood obesity (22). Key regulators of beef cattle carcass IMF (23).
BovineHD1400000206	FY, SCS	TONSL	1.65 (U)	Tonsoku like, DNA repair protein	Related to milk yield (24, 25) and affect the gamma–linolenic acid, long–chain saturated fatty acids and milk fat percent of the Canadian Holstein cows (26).
BovineHD4100004660	DCCI, FTLEG	LCORL	665.01 (D)	Ligand dependent nuclear receptor corepressor like	Affect human height (27), pig body length (28), horse height (29), chicken carcass weight (30), and the growth and development of cattle (31). Associated with the human skeletal frame size (32).
BovineHD1300012605	BFCI, FTLEG	PYGB	0.61 (D)	Glycogen phosphorylase B	Inhibition of glycogen utilization (33)
BTA−50244–no–rs	BFCI, DCCI	PTGER4	541.63 (D)	Prostaglandin E receptor 4	Relaxation to the smooth muscle (34), leading to the phosphorylation of glycogen synthase kinase−3 (35), involving in osteoporosis (36), and regulating lipid droplet size and mitochondrial activity in the white adipose tissue (37, 38).

*U, Upstream; D, Downstream.