Figure 6. Naringin (Nar) activated AMPK/Nrf2 signaling in HepG2 cells. A, B, and C, Western-blot results of Nrf2 and pAMPK/AMPK expression. D, E, and F, HepG2 cells were treated with dorsomorphin (Dor) (3 μM) and Nar (1 μM) for 8 h, and proteins (Nrf2 and pAMPK/AMPK) were detected by western blotting. G, H, and I, HepG2 cells were treated with brusatol (Bru) (200 nM) and Nar (3 μM) for 8 h, and proteins were detected by western blotting. Data are reported as means±SD (n=3). *P<0.05, **P<0.01 vs the APAP group. ^#P<0.05, ^##P<0.01, and ^###P<0.001 compared with cells treated only with Nar (ANOVA).