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. 2022 Sep 28;11:e76926. doi: 10.7554/eLife.76926

Figure 2. Positions along the posterior-to-anterior and inferior-to-superior axes in MNI space of quintile bins along the principal LPFC gradient.

(A) Positions of quintile bins in the left LPFC. (B) Positions of quintile bins in the right LPFC. Each colored sphere represents a brain region, with the color reflecting its network membership within the 17-Networks atlas (Yeo et al., 2011). SomMot: SomatoMotor, VisCent/Peri: Visual Central/Peripheral, SalVentAttn: Salience/Ventral Attention, DorsAttn: Dorsal Attention, TemPar: Temporo-Parietal, Cont: Executive Control, Default: Default Mode.

Figure 2.

Figure 2—figure supplement 1. Spatial correlation between the meta-analytic and resting-state connectivity gradients in the LPFC.

Figure 2—figure supplement 1.

Spatial correlation between the meta-analytic and resting-state connectivity gradients in the LPFC. The spatial layout of the resting-state connectivity gradients 1 and 3 from Margulies et al., 2016 is compared to that of the principal meta-analytic LPFC gradient using Pearson’s correlation. We observe (A) a moderately strong positive correlation between the principal meta-analytic and first resting-state connectivity gradient in the LPFC and (B) a weak negative correlation with the third gradient. These results suggest that the principal LPFC gradient can be understood as a local processing stream situated within a global spatial principle that explains unimodal-to-heteromodal brain activity. In the case of the LPFC, this activity organizing profile roughly extends from the caudal to rostral LPFC regions. *** p<0.0001.