Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 19;16:3609–3620. doi: 10.2147/DDDT.S330413

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Braun et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

ASAS 20, ASAS 40 response, ASAS partial remission, BASDAI 50, ASDAS LDA and ID, ASDAS CRP, SPARCC SIJ, nocturnal back pain, BASFI, ASQoL, ASAS-HI, BASMI and MASES in nr-axSpA patients treated with upadacitinib 15 mg/day vs placebo. *Nominal p=0·021. Analysis of multiplicity-controlled primary and key secondary endpoints at week 14. (A) Based on non-responder imputation incorporating multiple imputation analysis. (B) Multiplicity-controlled key secondary endpoints; ANCOVA analysis based on observed data for BASMI; MMRM analysis based on observed data for other endpoints; MASES was assessed in patients with baseline enthesitis. (C) Based on ANCOVA analysis; SPARCC MRI was assessed in patients with available baseline data up to 3 days after the first dose of study drug and available week 14 data up to the first dose of study drug in the open-label period. (D) Based on MMRM analysis. All endpoints were multiplicity controlled and sequentially tested (appendix p 10), except for SPARCC MRI spine score. Error bars show 95% CIs. MASES was not tested as part of the multiplicity-controlled test since BASMI did not meet statistical significance; only the nominal p value is presented, nominal p<0·05. Reprinted from Lancet, 400 (10349), Deodhar A, Van den Bosch F, Poddubnyy D et al. Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 369–379, with permission from Elsevier.28

Abbreviations: ASAS20, Assessment of SpondyloArthritis international Society 20 response; ASAS40, Assessment of SpondyloArthritis international Society 40 response; ASAS PR, Assessment of SpondyloArthritis international Society partial remission; ASDAS (CRP), Ankylosing Spondylitis (AS) Disease Activity Score C-reactive protein; ASQoL, AS Quality of Life Score; BASDAI50, at least 50% improvement from baseline in Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath AS Functional Index; BASMI, Bath AS Metrology Index; MASES, Maastricht AS Enthesitis Score; MMRM, mixed-effect model for repeated measures; SPARCC, Spondyloarthritis Research Consortium of Canada.