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. 2022 Oct 18;12:16952. doi: 10.1038/s41598-022-20970-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The SPRY domain of bovine TRIM5 is the determinant of anti-lentiviral activity. (a) (left) CRFK cells expressing TRIM5 proteins were infected with an HIV-1 vector encoding luciferase reporter protein. The infectivity was determined as relative light units (RLU) 2 days after infection. (right) Relative infectivity was calculated using the values in the left panel. (b) (left) CRFK cells expressing TRIM5 proteins were infected with an SIVmac vector encoding luciferase reporter protein. The infectivity was determined as relative light units (RLU) 2 days after infection. (right) Relative infectivity was calculated using the values in the left panel. (c) (left) CRFK cells expressing TRIM5 proteins were infected with an FIV vector encoding luciferase reporter protein. The infectivity was determined as relative light units (RLU) 2 days after infection. (right). Relative infectivity was calculated using the values in the left panel. (d) (left) CRFK cells expressing TRIM5 proteins were infected with an EIAV vector encoding luciferase reporter protein. The infectivity was determined as relative light units (RLU) 2 days after infection. (right) Relative infectivity was calculated using the values in the left panel. (e) (left) CRFK cells expressing TRIM5 proteins were infected with an MLV vector encoding luciferase reporter protein. The infectivity was determined as relative light units (RLU) 2 days after infection. (right) Relative infectivity was calculated using the values in the left panel.

The SPRY domain of bovine TRIM5 is the determinant of anti-lentiviral activity. (a) (left) CRFK cells expressing TRIM5 proteins were infected with an HIV-1 vector encoding luciferase reporter protein. The infectivity was determined as relative light units (RLU) 2 days after infection. (right) Relative infectivity was calculated using the values in the left panel. (b) (left) CRFK cells expressing TRIM5 proteins were infected with an SIVmac vector encoding luciferase reporter protein. The infectivity was determined as relative light units (RLU) 2 days after infection. (right) Relative infectivity was calculated using the values in the left panel. (c) (left) CRFK cells expressing TRIM5 proteins were infected with an FIV vector encoding luciferase reporter protein. The infectivity was determined as relative light units (RLU) 2 days after infection. (right). Relative infectivity was calculated using the values in the left panel. (d) (left) CRFK cells expressing TRIM5 proteins were infected with an EIAV vector encoding luciferase reporter protein. The infectivity was determined as relative light units (RLU) 2 days after infection. (right) Relative infectivity was calculated using the values in the left panel. (e) (left) CRFK cells expressing TRIM5 proteins were infected with an MLV vector encoding luciferase reporter protein. The infectivity was determined as relative light units (RLU) 2 days after infection. (right) Relative infectivity was calculated using the values in the left panel.