Table 1.

Frequency of CYP2D6 and CYP2C19 genotypes.

Gene	Baseline visit; N = 461 (95% CI)	Dropouts; N = 270 (95% CI)	Adherent; N = 191 (95% CI)
CYP2D6
PMs
*3/*4	0.009 (0.003–0.022)	0.007 (0.002–0.027)	0.010 (0.003–0.037)
*4/*4	0.039 (0.025–0.061)	0.037 (0.020–0.067)	0.042 (0.021–0.080)
*4/*4xN	0.002 (0.000–0.012)	0.004 (0.001–0.021)	NF
*4/*5	0.022 (0.012–0.039)	0.022 (0.010–0.048)	0.021 (0.008–0.053)
*4/*10	0.002 (0.000–0.012)	0.004 (0.001–0.021)	NF
*5/*5	0.004 (0.001–0.016)	0.004 (0.001–0.021)	0.005 (0.001–0.029)
*5/*6	0.002 (0.000–0.012)	NF	0.005 (0.001–0.029)
NMs
wt/wt	0.518 (0.473–0.564)	0.507 (0.448–0.566)	0.534 (0.463–0.603)
wt/*3	0.017 (0.009–0.034)	0.015 (0.006–0.038)	0.021 (0.008–0.053)
wt/*4	0.215 (0.180–0.254)	0.219 (0.173–0.272)	0.209 (0.158–0.273)
wt/*4xN	0.004 (0.001–0.016)	0.007 (0.002–0.027)	NF
wt/*5	0.050 (0.033–0.074)	0.059 (0.037–0.094)	0.037 (0.018–0.074)
wt/*6	0.019 (0.010–0.037)	0.026 (0.013–0.053)	0.010 (0.003–0.037)
wt/*10	0.024 (0.013–0.042)	0.030 (0.015–0.057)	0.016 (0.005–0.045)
wtx2/*3	0.002 (0.000–0.012)	0.004 (0.001–0.021)	NF
wtx2/*4	0.015 (0.007–0.031)	0.004 (0.001–0.021)	0.031 (0.014–0.067)
wtx2/*10	0.002 (0.000–0.012)	0.004 (0.001–0.021)	NF
UMs
wt/wtxN	0.052 (0.035–0.076)	0.048 (0.028–0.081)	0.058 (0.032–0.100)
CYP2C19
PMs
*2/*2	0.0152 (0.007–0.031)	0.019 (0.008–0.043)	0.010 (0.003–0.037)
NMs
wt/*2	0.200 (0.166–0.238)	0.189 (0.147–0.240)	0.215 (0.162–0.278)
wt/wt	0.427 (0.383–0.473)	0.437 (0.379–0.497)	0.414 (0.346–0.484)
*2/*17	0.089 (0.066–0.118)	0.089 (0.060–0.129)	0.089 (0.056–0.138)
UMs
wt/*17	0.252 (0.214–0.293)	0.256 (0.207–0.311)	0.246 (0.190–0.312)
*17/*17	0.017 (0.009–0.034)	0.011 (0.004–0.032)	0.026 (0.011–0.060)

PMs poor metabolizers (AS = 0), NM normal metabolizers (1 ≤ AS ≤ 2), UMs ultrarrapid metabolizers (AS > 2), NF not found.