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PK analysis of plasma concentrations, with ± SD, after intranasal (IN) and oral (PO) administration in male C57BL6 mice.
| Route | Dose (mg/kg) | Concentration (mg/mL) | Number of animals | Blood collection times (h) | Cmax (ng/mL) | Tmax (h) | AUCt/dose (h*kg*ng/mL/mg) |
|---|---|---|---|---|---|---|---|
| IN | 0.5 | 1.0 | 3 | 0.25, 1, 2, 4, 8, 24 | 177.97 ± 26.15 | 0.25 ± 0.00 | 188.05 ± 32.52 |
| IN | 1.25 | 2.5 | 3 | 325.95 ± 42.45 | 0.25 ± 0.00 | 150.62 ± 23.80 | |
| PO | 10 | 1.0 | 3 | 22.72 ± 4.42 | 0.75 ± 0.43 | 3.07 ± 0.92 | |
| PO | 25 | 2.5 | 3 | 33.67 ± 3.42 | 0.5 ± 0.43 | 2.00 ± 0.51 |
