Table 2.
Effect of remdesivir plus standard of care (SoC) compared to SoC only on patient-relevant outcomes after 1 year from hospitalization due to COVID-19-infection
| Outcome (Option categories in questionnaire) | Remdesivir, n = 98 (%) | SoC, n = 83 (%) | RR, 95% CI |
|---|---|---|---|
| How do you feel you have recovered from the COVID-19 infection you had a year ago? | 0.94, 0.47–1.90 | ||
| Fully or largely (1–2) | 83 (84.7) | 71 (85.5) | |
| About halfway recovered to not recovered at all (3–5) | 15 (15.3) | 12 (14.5) | |
| Exertional dyspnea, mMRC dyspnea scale | 0.61, 0.20–1.85 | ||
| No to slight dyspnea (mMRC 0–1) | 92 (93.9) | 76 (91.6) | |
| At least a need to walk slower than usually (mMRC 2–4) | 5 (5.1) | 7 (8.4) | |
| Excluded (paralyzed before COVID-19) | 1 | 0 | |
| Fatigue | 0.88, 0.54–1.44 | ||
| No or slight fatigue (1–2) | 74 (75.5) | 60 (72.2) | |
| Moderate or severe fatigue (3–4) | 24 (24.5) | 23 (27.7) | |
| Mobility, walking (EQ-5D-5L) | 1.03, 0.54–1.96 | ||
| No or slight problems (1–2) | 81 (82.7) | 69 (83.1) | |
| From moderate problems to unable to walk (3–5) | 17 (17.3) | 14 (16.9) | |
| Self-care, washing or dressing oneself (EQ-5D-5L) | 0.51, 0.13–2.08 | ||
| No or slight problems (1–2) | 95 (96.9) | 78 (94.0) | |
| From moderate problems to inability to wash or dress (3–5) | 3 (3.1) | 5 (6.0) | |
| Usual activities, e.g., work, study, housework, family or leisure activities (EQ-5D-5L) | 0.71, 0.32–1.55 | ||
| No or slight problems (1–2) | 88 (89.8) | 71 (85.5) | |
| From moderate problems to inability to do usual activities (3–5) | 10 (10.2) | 12 (14.5) | |
| Pain or discomfort (EQ-5D-5L) | 0.85, 0.44–1.63 | ||
| No or slight pain (1–2) | 83 (84.7) | 68 (81.9) | |
| From moderate to extreme pain (3–5) | 15 (15.3) | 15 (18.1) | |
| Anxiety or depression (EQ-5D-5L) | 1.27, 0.47–3.42 | ||
| No or slight problems (1–2) | 89 (90.8) | 77 (92.8) | |
| From moderate to extreme problems (3–5) | 9 (9.2) | 6 (7.2) |