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. 2022 Oct 2;28:101712. doi: 10.1016/j.ajoc.2022.101712

Table 1.

Described cases of HHV6 associated retinitis/uveitis/optic neuritis.3, 4, 5, 6, 7, 8 Abbreviations: PCR – Polymerase chain reaction; CSF – Cerebrospinal fluid; RT – Reverse transcriptase; IV – Intravenous; VEP – Visual evoked potentials.

Author and journal Date Age Immune status Site of isolation Laterality Treatment Outcome
Ogata et al. Jpn J Ophthalmol10 2011 63 Competent Aqueous/multiplex PCR Left Steroids + ganciclovir Recovered full vision
Moschettini et al. J Clin Virol11 2006 23 Competent CSF/Serum PCR; RT-nested PCR for HHV6 mRNA Bilateral Ganciclovir Relapses, ultimately successful treatment
Papageorgiou et al. Ocul Immunol Inflamm12 2014 22 Competent CSF Bilateral Acyclovir + steroids Recovered full vision
Maslin et al. J Infect13 2007 81 DM, AML (10 months remission) CSF PCR, Aqueous humor PCR Bilateral Intravitreal foscarnet → ganciclovir Recovered previous vision
Mechai et al. J Med Virol14 2007 59 HIV, CD4 > 200 CSF, blood Bilateral IV foscarnet + IV ganciclovir→ cidofovir + valganciclovir Recovered vision, VEP remained abnormal
Hino et al. Br J Haematol15 2015 39 MDS s/p HLA matched BMT CSF PCR Bilateral Foscarnet IV Stabilized but persistent memory deficit
Oberacher-Velten et al. Graefes Arch Clin Exp Ophthalmol16 2005 31 Diabetes Blood serology Bilateral Foscarnet IV Recovered vision