TABLE 2.
Demographic information and drug-specific parameters in virtual elderly and pediatric populations.
| Parameter type | Adult | Elderly | Term infant | Infant | Children | Adolescent |
|---|---|---|---|---|---|---|
| Individual | ||||||
| Age (year) | 25.7 | 70.5 | 13.5 days | 1 | 6.5 | 14.5 |
| Weight (kg) | 60.98 | 58.04 | 4.28 | 10.66 | 21.46 | 51.37 |
| Height (cm) | 167.60 | 165.40 | 54.11 | 81.49 | 118.94 | 162.81 |
| BMI (kg/m2) | 21.71 | 21.21 | 14.63 | 16.05 | 15.17 | 19.38 |
| fu (%) | 18 | 17.56 | 21.47 | 19.57 | 18.63 | 18.26 |
| Population | ||||||
| Age (years) | 18–60 | 60–81 | 0–27 days | 28 days-23 months | 1–11 | 12–17 |
| Number of individuals | 100 | 100 | 100 | 100 | 100 | 100 |
| Proportion of females | 50% | 50% | 50% | 50% | 50% | 50% |
| Metabolism and Elimination | ||||||
| Total Clearance (L/h) | 9 | 8.672 | 1.23 | 2.433 | 4.112 | 7.914 |
| Total clearance (L/h/kg) | 0.147 | 0.149 | 0.287 | 0.228 | 0.192 | 0.154 |
| Total Hepatic Clearance (L/h/kg) | 0.09 | 0.0896 | 0.17 | 0.14 | 0.12 | 0.092 |
| Hepatic Specific Clearance (1/min) | 0.36 | 0.34 | 0.04 | 0.09 | 0.15 | 0.30 |
| Renal Clearances (L/h/kg) | 0.05 | 0.0523 | 0.10 | 0.08 | 0.07 | 0.054 |
| Renal Specific Clearance (1/min) | 0.70 | 0.69 | 0.09 | 0.07 | 0.31 | 0.63 |