TABLE 7.
Pharmacokinetic parameters of 50 mg or 4 mg/kg PTU orally in healthy elderly and pediatric populations.
| Dose | Parameter | Adult | Elderly | Term infant | Infant | Children | Adolescent |
|---|---|---|---|---|---|---|---|
| 50 mg | AUC0-t (ng*h/mL) | 4278.05 | 5021.03 | 121152.07 | 54131.18 | 17775.04 | 5658.85 |
| Tmax (h) | 0.95 | 1.00 | 2.00 | 1.45 | 1.15 | 1.05 | |
| Cmax (ng/ml) | 1185.04 | 1317.97 | 15539.52 | 9171.39 | 4016.91 | 1446.26 | |
| 4 mg/kg | AUC0-t (ng*h/mL) | — | — | 64141.05 | 44606.55 | 30155.37 | 20291.40 |
| Tmax (h) | — | — | 1.30 | 1.25 | 1.25 | 1.20 | |
| Cmax (ng/ml) | — | — | 8116.81 | 7367.48 | 6350.62 | 5168.29 |