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. 2022 Oct 5;13:997765. doi: 10.3389/fimmu.2022.997765

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Copyright © 2022 Lv, Wu, Jian, Zhang, Lou, Kang, Hou, Li, Li, Sun and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of immunotherapy and screening of chemotherapeutic drugs. (A) Prediction of ICB treatment response of osteosarcoma based on the TIDE, dysfunction, CD274, and exclusion scores. (B) Flow chart of chemosensitivity prediction based on the osteosarcoma risk score. (C) Heatmap of the sensitivity of 40 chemotherapeutic drugs screened in the CTRP database. (D) Heatmap of the sensitivity of 62 chemotherapeutic drugs screened in the PRISM database. (E) Intersection with drugs with CMap scores< −90 in the CTRP database. (F) Intersection with drugs with CMap scores< −90 in the PRISM database.