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. 2022 Oct 5;13:1003614. doi: 10.3389/fphar.2022.1003614

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Copyright © 2022 Ma, Zhou, Yang, Xue, Xie, Li and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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At 4–12 weeks, effects of MMXY on body weight, SPT, OFT, CORT and DA of CUMS rats in control group, model group, MMXY-H group, MMXY-L and CBZ groups. (A) Weight of rats at 4-12 weeks (n = 8). (B) SPT results at weeks 8 and 12 (n = 8). (C) OFT results at weeks 8 and 12, including the central grid residence time, horizontal activity, vertical activity and grooming times (n = 8). Results are shown as the mean ± SD. ^# p < 0.05 and ^## p < 0.01 vs. control group; *p < 0.05 and **p < 0.01 vs. model group. (D,E) At 12 weeks, the level of CORT and DA in each group (n = 8). Results are shown as the median (P25, P75). ^# p < 0.05 and ^## p < 0.01 vs. control group; *p < 0.05 and **p < 0.01 vs. model group.