TABLE 2.

Diagnostic accuracy summary of subgroup analysis.

	SEN (95% CI)	SPE (95% CI)	AUC (95% CI)	Heterogeneity (%)
Country
America	0.650 (0.559, 0.732)	0.809 (0.764, 0.848)	0.82 (0.79, 0.85)	91.17
Other	0.666 (0.543, 0.769)	0.919 (0.836, 0.962)	0.90 (0.87, 0.92)	0.0
Causal classification
Secondary cause	0.620 (0.513, 0.717)	0.822 (0.754, 0.874)	0.82 (0.79, 0.85)	65.92
All types	0.680 (0.577, 0.768)	0.837 (0.793, 0.873)	0.85 (0.82, 0.88)	81.88
Time interval
>90	0.557 (0.489, 0.623)	0.867 (0.806, 0.911)	0.81 (0.77, 0.84)	0.0
≦90	0.685 (0.582, 0.772)	0.825 (0.714, 0.899)	0.84 (0.81, 0.87)	87.30
Sample
<100	0.646 (0.561, 0.724)	0.823 (0.753, 0.877)	0.82 (0.78, 0.85)	67.91
>100	0.663 (0.533, 0.773)	0.843 (0.799, 0.878)	0.85 (0.82, 0.88)	75.02
Year
Before 2015	0.689 (0.592, 0.771)	0.843 (0.774, 0.893)	0.85 (0.82, 0.88)	76.81
After 2015	0.594 (0.501, 0.680)	0.827 (0.767, 0.875)	0.80 (0.77, 0.84)	53.22

AUC, area under the curve; SEN, sensitivity; SPE, specificity.