TABLE 2.
Summary of mannitol concentrations by timepoint
| 50 g mannitol (N = 15) | 100 g mannitol (N = 11) | 150 g mannitol (N = 16) | |
|---|---|---|---|
| Mannitol plasma concentrations (mg/ml) | |||
| T 0 | |||
| n | 15 | 11 | 16 |
| Mean (SD) | 0.0006 (0.00193) | 0.0002 (0.00062) | 0.0001 (0.00033) |
| Median | 0.0000 | 0.0000 | 0.0000 |
| Q1; Q3 | 0.0000; 0.0000 | 0.0000; 0.0000 | 0.0000; 0.0000 |
| Min; max | 0.000; 0.007 | 0.000; 0.002 | 0.000; 0.001 |
| T 1 | |||
| n | 15 | 11 | 16 |
| Mean (SD) | 0.6218 (0.14869) | 0.9777 (0.28581) | 1.2996 (0.38100) |
| Median | 0.6387 | 0.9201 | 1.2922 |
| Q1; Q3 | 0.4951; 0.7018 | 0.8375; 1.2190 | 0.9655; 1.6511 |
| Min; max | 0.402; 0.951 | 0.532; 1.617 | 0.715; 1.798 |
| T 2 | |||
| n | 15 | 11 | 16 |
| Mean (SD) | 0.4689 (0.12169) | 0.8647 (0.26881) | 1.1747 (0.40002) |
| Median | 0.4408 | 0.8498 | 1.2887 |
| Q1; Q3 | 0.3881; 0.5886 | 0.6217; 1.0242 | 0.7649; 1.4889 |
| Min; max | 0.274; 0.673 | 0.499; 1.392 | 0.520; 1.700 |
| T 4 | |||
| n | 15 | 11 | 16 |
| Mean (SD) | 0.2734 (0.08228) | 0.5606 (0.22477) | 0.7339 (0.35330) |
| Median | 0.2661 | 0.6241 | 0.7427 |
| Q1; Q3 | 0.2123; 0.3086 | 0.3269; 0.8144 | 0.4220; 0.9672 |
| Min; max | 0.160; 0.472 | 0.238; 0.845 | 0.241; 1.281 |
| T 8 | |||
| n | 14 a | 11 | 16 |
| Mean (SD) | 0.0931 (0.05362) | 0.1889 (0.09435) | 0.2754 (0.16519) |
| Median | 0.0761 | 0.2374 | 0.2605 |
| Q1; Q3 | 0.0640; 0.0818 | 0.0987; 0.2619 | 0.1266; 0.4063 |
| Min; max | 0.032; 0.215 | 0.050; 0.316 | 0.070; 0.629 |
Note: T 0 = baseline before mannitol self‐administration; T 1 = 1 h, T 2 = 2 h, T 4 = 4 h, T 8 = 8 h after completion of mannitol self‐administration.
Abbreviations: Q1, first quartile; Q3, third quartile; SD, standard deviation.
a
The plasma sample for one patient was collected outside of the protocol‐defined time window, and therefore the sample result was excluded from the calculation of summary statistics.