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. 2022 Aug 12;15(10):2392–2402. doi: 10.1111/cts.13368

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© 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Apparent permeability coefficient (P _app) and efflux ratio (ER) values versus age for probe compounds determined in this study. Each point represents a mean value per patient. Light blue closed circles: mucosal to serosal transport of the substrate. Dark blue open circles: serosal to mucosal transport of the substrate. Black circles: mean ER per patient. (a) transcellular transport determined with substrate propranolol. (b) Paracellular transport determined with substrate enalaprilat. (c) Transport by MDR1 determined with substrate talinolol. Spearman correlation showed a correlation for MDR1 with age Rs value of 0.49 (p = 0.0283). (d) Transport by BCRP determined with substrate rosuvastatin. No correlation between ER of talinolol and rosuvastatin was found, Rs value of 0.57 (p > 0.05).