TABLE 2.

Estimated marginal mean ± SE calculated using mixed model statistics and means ± SD per age group and transport direction of the different substrates

Drug	Age group	Direction	Estimated marginal mean ± SE (×10–6 cm/s)	Mean ± SD (×10–6 cm/s)	N, n
Propranolol	Pediatric	M > S	7.98 ± 1.45	7.49 ± 4.58	11, 19
		S > M	7.74 ± 1.47	8.27 ± 4.70	10, 16
	Adult	M > S	11.98 ± 1.28	12.38 ± 6.15	11, 26
		S > M	10.34 ± 1.27	10.65 ± 5.02	12, 26
Enalaprilat	Pediatric	M > S	2.91 ± 0.37	2.76 ± 1.36	11, 21
		S > M	2.93 ± 0.39	3.02 ± 0.9	10, 16
	Adult	M > S	2.95 ± 0.34	2.94 ± 1.69	11, 26
		S > M	2.65 ± 0.34	2.67 ± 1.48	12, 25
Talinolol	Pediatric	M > S	4.94 ± 1.33	4.80 ± 3.11	11, 19
		S > M	11.06 ± 1.39	11.32 ± 4.26	10, 16
	Adult	M > S	6.60 ± 1.16	7.00 ± 4.52	11, 15
		S > M	17.87 ± 1.15	18.27 ± 6.87	12, 26
Rosuvastatin	Pediatric	M > S	3.80 ± 0.88	4.73 ± 2.04	11, 18
		S > M	7.53 ± 1.00	7.53 ± 3.66	10, 14
	Adult	M > S	6.32 ± 0.97	6.32 ± 2.75	11, 26
		S > M	11.16 ± 0.91	11.16 ± 5.49	12, 17

Note: N = amount of patients, n = amount of chambers.