TABLE 1.

Mitochondrial dynamics dysfunction induced hearing loss.

Research model	Target gene	Disease	Hearing loss type	Fusion/Fission	Hearing loss/Mitochondrial mechanism	References
Patients with ADOA disease	OPA1	Autosomal dominant optic atrophy	Auditory neuropathy	Pro-fusion	Neuronal mitochondria fragmented	Ham et al., 2019
Patients with CMT disease	MFN2	Charcot-Marie-Tooth disease	Auditory neuropathy	Pro-fusion	Unmyelinated auditory nerve dysfunction	Choi et al., 2020
C57BL/6J mice	Drp1	Age related hearing loss	Age related hearing loss	Pro-fission	Inhibit Drp1, promote the progression of presbycusis	Lin et al., 2019
Fibroblasts from FRDA patient	FXN	Friedreich’s ataxia	Auditory neuropathy	Pro-fusion	Iron accumulation and oxidative damage in mitochondria	Rojas et al., 2021
Gene knockout mice	WFS1	Wolfram syndrome	Auditory neuropathy	Pro-fusion	Upregulation mitochondrial dysfunction genes	Cagalinec et al., 2016