TABLE 2.

Longitudinal analysis of lymphocyte subsets and function in patients with chromosome 22q11.2 deletion syndrome in the first year of life

Determination	Results for patients with chromosome 22q11.2 deletion				P valuea	Values for 1-yr-old healthy controls
	Newborns (n = 19)		1-yr-olds (n = 19)
	Mean	5–95% range	Mean	5–95% range		Mean	5–95% range
Absolute lymphocyte count (cells/mm3)	3,164	2,183–4,142	4,631	3,563–5,700	0.041	5,500	2,600–10,400
CD3
Cells/mm3	1,625	1,058–2,192	1,854	1,475–2,235	0.497	3,400	1,600–6,700
%	50.5	42–59	42.6	37–48	0.028	65	54–76
CD4
Cells/mm3	1,117	753–482	1,233	1,000–1,465	0.601	2,300	1,000–4,600
%	35.4	29–41	28.2	25–31	0.006	44	31–54
CD8
Cells/mm3	480	290–670	502	362–643	0.846	1,100	400–2,100
%	14.4	12–17	11.5	9–14	0.068	18	12–28
TCRγδ
Cells/mm3	110	49–171	227	24–429	0.199
%	2.3	1–4	3.4	3–4	0.091
CD5/19
Cells/mm3	74	13–134	278	154–402	0.011
%	2.1	1–3	7.2	4–10	0.003
CD19
Cells/mm3	484	329–638	1,832	1,260–2,403	<0.001	1,400	600–2,700
%	21.5	16–27	39.4	34–45	<0.001	25	15–39
CD16/56
Cells/mm3	835	364–1,305	785	407–1,163	0.781	400	200–1,200
%	21.0	14–28	28.8	1–58	0.510	7	3–17
PHA (n = 13)
cpm	52,867	31,826–73,908	82,594	67,579–97,609	0.002
SI	107	55–160	373	277–468	<0.001
ConA (n = 13)
cpm	54,005	31,724–76,286	62,084	44,550–79,617	0.541
SI	98	60–136	319	197–441	0.004
PWM (n = 13)
cpm	32,603	20,955–44,252	30,843	22,856–38,831	0.788
SI	59	37–82	154	91–218	0.010

^aP values < 0.05 are boldfaced.