Table 2.
Schedule of events during experimental day
| Procedure | Time point (min post-baclofen/placebo) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| aBaseline | 15 | 30 | 60 | 90 | 120 | 180 | 240 | 300 | |
| NEWS2 | x | – | – | x | – | x | x | x | x |
| SpO2 | x | xb | xb | x | xb | x | x | x | x |
| RR | x | xb | xb | x | xb | x | x | x | x |
| BP | x | – | – | x | – | x | x | x | x |
| HR | x | – | – | x | – | x | x | x | x |
| Body temperature | x | – | – | x | – | x | x | x | x |
| LOC | x | – | – | x | – | x | x | x | x |
| GCS | x | – | – | x | – | x | x | x | x |
| ECG | x | – | – | – | – | x | – | – | x |
| tcCO2 | x | x | x | x | x | x | x | x | x |
| SHAS | x | – | – | x | – | x | x | x | x |
| DEQ | x | – | – | x | – | x | x | x | x |
| VAS craving/anxiety | x | – | – | x | – | x | x | x | x |
| Blood plasma/serum | x | – | – | x | – | x | x | – | x |
| COWS | x | – | – | – | – | x | – | – | x |
RR respiratory rate, BP blood pressure, HR heart rate, LOC level of consciousness
aBaseline refers to the measurements obtained prior to time 0, which represents the time at which baclofen/placebo is administered. Shaded areas are measures comprising the NEWS2 score
bAt these time points, SpO2 and RR measures will be taken in addition to those associated with the NEWS2