NCT01768832.

Trial name or title	Exercise and Parkinson's: Comparing Interventions and Exploring Neural Mechanisms
Methods	Randomised controlled trial with parallel group assignment
Participants	Estimated enrollment: 120, aged above 30 years Inclusion criteria: Diagnosis of Parkinson's Disease, at least grade 3/5 strength and normal joint ranges of motion in both legs, good vision, independent ambulation for 10 feet with or without assistive devices, normal gross somatosensory function in the feet Exclusion criteria: Other medical condition with exercise being a contraindication, abnormal brain imaging, evidence or history of other neurological or muscular conditions, failed to pass MRI procedure
Interventions	3 arms: (1) Treadmill training 2 times a week (120 min per week) for 12 weeks (2) Tango dance training 2 times a week (120 min per week) for 12 weeks (3) Stretching 2 times a week (120 min per week) for 12 weeks
Outcomes	Primary Outcome Measures: Change in Walking Velocity from Baseline to 3 Months Secondary Outcome Measures: Change in Blood oxygen level dependent signal from baseline to 3 months, Change in Mini Balance Evaluation Systems Test (Mini‐BESTest) from baseline to 3 months, Change in PDQ‐39 from baseline to 3 months, Change in Movement Disorder Society Unified Parkinson Disease Rating Scale (UPDRS) Subscale III from baseline to 3 months, Change in Mini Balance Evaluation Systems Test (Mini‐BESTest) from 3 to 6 months, Change in UPDRS Subscale III from 3 months to 6 months, Change in PDQ‐39 from 3 months to 6 months, Change in walking velocity from 3 months to 6 months
Starting date	February 2013
Contact information	Washington University School of Medicine St. Louis, Missouri, United States, 63108 Martha Hessler: hesslerm@wusm.wustl.edu Gammon M Earhart, PhD, PT: earhartg@wusm.wustl.edu
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