TABLE 1.
The minimum inhibitory concentration (MIC) values of commonly clinical antibiotics and plumbagin against colistin-resistant clinical isolates.
| Strains | Antibiotics | IPM | ATM | LVX | FEP | MEM | GEN | CIP | TOB | PIP | CZA | COL | PLU |
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| Breakpoints (S–R) | 2–8 | 8–32 | 1–4 | 8–32 | 2–8 | 4–16 | 0.5–2 | 4–16 | 16–128 | 8–16 | 2–4 | NA | |
| TL1671 | MIC (μg/ml) | 2S | 8S | 1S | 8S | 0.5S | 2S | 0.25S | 1S | 8S | 4S | 8R | >256 |
| TL1736 | 16R | 8S | 1S | 2S | 256R | 32R | 1I | 8I | 256R | 2S | 8R | >256 | |
| TL2314 | 4I | 16I | 2S | 16I | 4I | 8I | 0.5S | 2S | 256R | 4S | 4R | >256 | |
| TL2917 | 16R | 32R | 2S | 16I | 256R | 8I | 0.25S | 8I | 256R | 8I | 4R | >256 | |
| TL2967 | 16R | 128R | 16R | 32R | 128R | 8I | 8R | 8I | 256R | 16R | 4R | >256 | |
| TL3008 | 16R | 4S | 1S | 4S | 8R | 16R | 0.5S | 4S | 8S | 4S | 64R | 128 | |
| TL3086 | 128R | 128R | 8R | 16I | 128R | 128R | 16R | 128R | 128R | 4S | 128R | >256 | |
MIC, COL-R PA inhibitory concentration; IPM, imipenem; ATM, aztreonam; LVX, levofloxacin; FEP, cefepime; MEM, meropenem; GEN, gentamicin; CIP, ciprofloxacin; TOB, tobramycin; PIP, piperacillin; CZA, ceftazidime/avibactam; COL, colistin; S, Susceptible; I, intermediate; R, resistance. NA is not applicable.