Table 5. Univariate and Multivariate Analyses of the Cancer and Aging Research Group Chemotherapy Toxicity Prediction Model.
| Characteristic | Grade 3-5 toxic effects | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
| Yes | No | OR (95% CI) | P value | OR (95% CI) | P value | ||
| Age >72 y | 104 | 43 | 1.21 (0.87-1.68) | .26 | 1.31 (0.90-1.91) | >.99 | |
| Gastrointestinal or genitourinary cancer (referent, other cancers) | 58 | 39 | 0.67 (0.50-0.91) | .01 | 0.59 (0.42-0.83) | .03 | |
| Chemotherapy dosing (referent, reduced dose) | 78 | 32 | 1.13 (0.84-1.53) | .42 | 1.35 (0.95-1.91) | .99 | |
| No. of chemotherapy drugs (referent, monochemotherapy) | 104 | 45 | 1.12 (0.80-1.57) | .50 | 1.07 (0.74-1.55) | >.99 | |
| Hemoglobin (<10 g/dL in women, <11 g/dL in men) | 46 | 9 | 1.44 (1.11-1.88) | .006 | 1.60 (1.21-2.14) | .01 | |
| Creatinine clearance (<34 mL/min) | 10 | 2 | 1.34 (0.80-2.24) | .27 | 1.60 (0.89-2.85) | >.99 | |
| Hearing, fair or worsened | 16 | 7 | 1.03 (0.64-1.65) | .91 | 0.82 (0.48-1.40) | >.99 | |
| No. of falls in the last 6 mo (referent, ≥1 fall) | 18 | 6 | 1.13 (0.81-1.56) | .47 | 1.10 (0.74-1.52) | >.99 | |
| IADL, taking medicine with some help or unable | 16 | 6 | 1.26 (0.47-3.38) | .65 | 0.60 (0.19-1.94) | >.99 | |
| Medical Outcomes Study | |||||||
| Walking 1 block somewhat limited/a lot | 43 | 12 | 1.39 (0.97-2.00) | .07 | 1.23 (0.81-1.87) | >.99 | |
| Decreased social activity due to physical or emotional health | 83 | 31 | 1.59 (0.87-2.89) | .13 | 1.54 (0.77-3.10) | >.99 | |
Abbreviations: IADL, instrumental activities of daily living; OR, odds ratio.
SI conversion factor: To convert hemoglobin to grams per liter, multiply by 10.