The EC50 (mM) values of derivatives 4, 8, 12, 13, 16, 18, and 23–25 on MT1 and MT2 receptorsa.
| Compounds | EC50 (mM) | |
|---|---|---|
| MT1 | MT2 | |
| 4 | 0.70 ± 0.09 | 0.52 ± 0.03 |
| 8 | 0.25 ± 0.03 | 0.35 ± 0.04 |
| 12 | 0.44 ± 0.08 | 0.13 ± 0.02 |
| 13 | 0.36 ± 0.02 | 0.36 ± 0.09 |
| 16 | 0.31 ± 0.05 | 0.35 ± 0.04 |
| 18 | 0.33 ± 0.05 | 0.26 ± 0.07 |
| 23 | 0.46 ± 0.06 | 0.38 ± 0.05 |
| 24 | 0.38 ± 0.03 | 0.27 ± 0.07 |
| 25 | 0.42 ± 0.04 | 0.43 ± 0.03 |
a
EC50 values for derivatives 4, 8, 12, 13, 16, 18, and 23–25 were determined from the dose–response curves obtained with seven concentrations in the range of 0.02–2 mM, and calculated by GraphPad Prism 6.0 software.