Effects of selected substitution of R2 on the kinase inhibitory activity of 1H-1,2,4-triazole derivatives.
| ||||||||
|---|---|---|---|---|---|---|---|---|
| Cpd. | R2 | Axl IC50 (nM) | Cpd. | R2 | Axl IC50 (nM) | Cpd. | R2 | Axl IC50 (nM) |
| w1 |
|
15 | w8 |
|
46 | w15 |
|
30 |
| w2 |
|
12 | w9 |
|
555 | w16 |
|
101 |
| w3 |
|
9 | w10 |
|
14 | w17 |
|
100 |
| w4 |
|
30 | w11 |
|
28 | w18 |
|
15 |
| w5 |
|
16 | w12 |
|
185 | w19 |
|
10 |
| w6 |
|
50 | w13 |
|
48 | w20 |
|
12 |
| w7 |
|
51 | w14 |
|
11 | |||