Effects of various five-membered heteroaromatic rings on the kinase inhibitory activity of diphenylpyrimidine–diamine derivatives.
| |||||||
|---|---|---|---|---|---|---|---|
| Cpd. | R3 | R4 | Axl IC50 (nM) | Cpd. | R3 | R4 | Axl IC50 (nM) |
| m1 |
|
|
8 | m9 |
|
|
10 |
| m2 |
|
|
16 | m10 |
|
|
18 |
| m3 |
|
|
30 | m11 |
|
|
25 |
| m4 |
|
|
11 | m12 |
|
|
12 |
| m5 |
|
|
22 | m13 |
|
|
22 |
| m6 |
|
|
5 | m14 |
|
|
36 |
| m7 |
|
|
49 | m15 |
|
|
169 |
| m8 |
|
|
23 | m16 |
|
|
5 |