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. 2022 Jul 20;13(10):1246–1264. doi: 10.1039/d2md00153e

Liver microsomal stability of four compounds.


Cpd.	Axl^a IC₅₀ (nM)	Human		Rat
Cpd.	Axl^a IC₅₀ (nM)	T _1/2 min	Clint mL min⁻¹ kg⁻¹	T _1/2 min	Clint mL min⁻¹ kg⁻¹
m6	5	155.9	CL_hep = 11.2	153.1	CL_hep = 16.2
m6	5	155.9	CL_{in vivo} = 7.2	153.1	CL_{in vivo} = 12.5
m12	12	36.2	CL_hep = 48.0	6.4	CL_hep = 388.9
m12	12	36.2	CL_{in vivo} = 14.5	6.4	CL_{in vivo} = 48.3
m13	22	74.2	CL_hep = 23.4	15.4	CL_hep = 161.8
m13	22	74.2	CL_{in vivo} = 11.0	15.4	CL_{in vivo} = 41.2
m16	5	60.6	CL_hep = 28.7	28.3	CL_hep = 87.7
m16	5	60.6	CL_{in vivo} = 12.0	28.3	CL_{in vivo} = 33.9
TP-0903	15	2.7	CL_hep = 645.7	4.3	CL_hep = 581.9
TP-0903	15	2.7	CL_{in vivo} = 20.1	4.3	CL_{in vivo} = 50.4

^a

These data were used from Table 4.