Pharmacokinetic data of compounds m6, m16, and TP-0903 in rats.
| Parameter | m6 | m16 | TP-0903 | |||
|---|---|---|---|---|---|---|
| PO 5 mg kg−1 | IV 1 mg kg−1 | PO 5 mg kg−1 | IV 1 mg kg−1 | PO 5 mg kg−1 | IV 1 mg kg−1 | |
| AUClast (ng h−1 mL−1) | 661 | 497 | 1180 | 422 | 158 | 187 |
| C max (ng mL−1) | 169 | 337 | 83.9 | 56.3 | 46.8 | 89.8 |
| CL (mL h−1 kg−1) | NA | 1.95 | NA | 2.20 | NA | 4.97 |
| T 1/2 (h) | 1.32 | 1.49 | 6.45 | 6.6 | 2.94 | 1.77 |
| F% | 26.6 | 56.1 | 21.5 | |||