In vitro cytotoxic activity (mean IC50 values ± standard deviations) of lead compounds 17, 20, 21, 26, 31, 33, 36 and 38 against DU-145 (androgen-independent prostate cancer), LNCaP (androgen-dependent prostate cancer), Jukart (the T-cell leukemia cell line) and Jurkat J.γ1 cancer cell lines.
| Compound | IC50 values (μM) | |||
|---|---|---|---|---|
| DU-145 | LNCaP | Jurkat | Jurkat J.γ1 | |
| 17 | >20 | 15 ± 0.8 | 9 ± 0.7 | NI |
| 20 | 13.6 ± 2.9 | 8 ± 0.7 | 3 ± 0.3 | NI |
| 21 | >20 | 16 ± 1.1 | 11 ± 0.7 | NI |
| 26 | >20 | 13 ± 1.5 | 5 ± 0.3 | NI |
| 31 | 9.3 ± 1 | 5 ± 0.5 | 3 ± 0.6 | 2 ± 0.2 |
| 33 | 17.7 ± 3.3 | 11 ± 2 | 9 ± 1.3 | >20 |
| 36 | 11 ± 2.4 | 5 ± 0.4 | 5 ± 1.2 | NT |
| 38 | 5 ± 1.1 | 4 ± 0.3 | 3 ± 0.6 | 0.9 ± 0.1 |