Table 1:

Summary of the adaptation results.

No.	${\text{MTD}}_{𝒪}$	${\text{MLD}}_{𝒪}$	${\text{NTCP}}_{𝒪}$	RP grade	Update fx	P(RP)	$\widehat{\text{DMF}}$	Adapt	${\text{MTD}}_{𝒜}$	${\text{MLD}}_{𝒜}$	${\text{NTCP}}_{𝒜}$
1	76.70	11.30	0.06	1	36/37	0.01	0.38	2	79.5	11.7	0.01
2	61.40	19.66	0.17	1	20/30	0.09	0.61	2	78.9	17.2	0.17
3	74.99	18.05	0.13	1	31/37	0.12	0.96	2	79.49	18.79	0.13
4	74.70	16.60	0.11	1	31/37	0.15	1.13	2	79.7	17.4	0.17
5	77.20	15.78	0.10	1	12/37	0.19	0.94	2	79.77	16.89	0.20
6	76.27	19.20	0.12	2	28/37	0.26	1.15	1.a	76.12	17.2	0.20
7	75.40	23.40	0.20	3	29/33	0.34	1.21	1.a	73.4	19.2	0.20
8	71.82	24.48	0.22	2	23/33	0.54	1.30	1.b	64.82	20.51	0.36
9	73.40	16.86	0.19	2	30/35	0.64	2.04	1.b	54.4	14.68	0.48
10	65.98	24.26	0.22	3	28/30	0.67	1.63	1.b	65.43	23.46	0.63
11	82.20	25.20	0.24	3	25/37	0.68	1.58	1.b	65.9	19.8	0.41
12	75.70	15.98	0.11	2	28/33	0.68	2.14	1.b	65.14	13.64	0.50
13	71.98	22.12	0.19	3	25/30	0.73	1.82	1.b	65.68	18.86	0.53
14	77.68	24.10	0.28	3	28/30	0.76	1.60	1.b	66.12	20.71	0.62
15	72.05	23.91	0.21	4	28/30	0.76	1.79	1.b	65.72	21.66	0.64
Mean/Median*/Mode†
All	73.83	20.06	0.17	2*	28*/33*	0.44	1.35	1.b†	70.67	18.11	0.35
RP2+=0	73.00	16.28	0.11	1*	31*/37*	0.11	0.80	2†	79.47	16.40	0.14
RP2+ = 1	74.25	21.95	0.20	3*	28*/33*	0.61	1.63	1.b†	66.27	18.97	0.46

MTD = mean tumor dose; MLD = mean lung dose; fx: fraction; P(RP): BN-predicted risk; $\widehat{\text{DMF}}$: pat ient-specific dose modifying factor; Adapt: Adaptation type: (1.a) dose de-escalation, (1.b) minimizing NTCP, (2) dose escalation; $𝒪$: Original plan; $𝒜$: Adapted plan. MLD and MTD are given in Gy(RBE).