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. 2022 Oct 5;35(10):1720–1746. doi: 10.1021/acs.chemrestox.2c00160

Figure 6.

Figure 6

Approaches for measuring and targeting MG, MG-AGEs, and RAGE. (A) MG-AGEs can be quantified in vitro and in biological samples using LC-MS/MS. Example chromatogram is shown of the elution of MG-modified protein and DNA. (B) Molecules such as aminoguanidine and curcumin can be used to scavenge MG. MG and the formation of MG-AGEs can be targeted via scavenger compounds and using thiamine or benfoatiamine. AGEs can be targeted using sRAGE or alagebrium. RAGE activation can be inhibited using DNA aptamers, anti-RAGE antibodies, fusion proteins, peptides, or pharmacological inhibitors. Created with BioRender.com.