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. 2022 Oct 17;17:26331055221129641. doi: 10.1177/26331055221129641

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Schematic of early cellular events following mild neuronal deformation. (A) Working model of neuronal response to mild deformation under basal APP cleavage. (B) Working model of neuronal response to mild deformation after reduced APP cleavage, imposed genetically or pharmacologically.