Figure 2.

(A) Ibrutinib and zanubrutinib inhibited cell proliferation in a dose-dependent manner. (B-C) Ibrutinib and zanubrutinib were strongly cytostatic toward Raji cell, and the 2 BTK inhibitors performed slight inhibition in CD19 CAR-T cells at low concentration but obvious suppression at high concentration. (D-E) Lymphoma cell lines exhibited dose-dependent increases in apoptosis by ibrutinib and zanubrutinib. (F) The 2 BTK inhibitors induced slight apoptosis in CD19 CAR-T cell. Abbreviations: CD19, cluster of differentiation 19; CAR-T, chimeric antigen receptor T cell; BTK, Bruton's tyrosine kinase