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(A) The PD-1 expression on CD19 CAR-T cells obviously increased when co-cultured with U-2932 cells, the PD-1 expression can’t be decreased when ibrutinib added in the culture system. But zanubrutinib can’t reduce the PD-1 expression increase. (B) There was no combined effect of zanubrutinib with CD19 CAR-T cell on cytotoxicity in Raji cell in vitro. Abbreviations: CD19, cluster of differentiation 19; CAR-T, chimeric antigen receptor T cell; PD-1, programed cell death protein 1
