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The evolution of CAR-T cell structure. There are five generations of CAR-T cells to date. scFv is currently the most commonly used targeting domain for CAR-T cells, and VHH is also emerging as a targeting domain for CAR-T cells with great potential. VH: heavy chain variable domain; VL: light chain variable domain; scFv: single-chain fragment variable; VHH: single variable domain on a heavy chain
