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. 2022 Oct 19;21:201. doi: 10.1186/s12943-022-01669-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Common CAR-T cell therapy targets in solid tumors. EGFR: epidermal growth factor receptor; GD2: ganglioside2; MUC1: mucin 1; NKG2DL: natural killer group 2 member D ligand; HER2: human epidermal growth factor receptor 2; HNSCC: head and neck squamous cell carcinoma; TC: thyroid cancer; ICAM-1: intercellular adhesion molecule-1; LCa: lung cancer; PD-L1: programmed death-ligand 1; MSLN: mesothelin; ROR: receptor tyrosine kinase like orphan receptor; CEA: carcinoembryonic antigen; NY-ESO-1: New York esophageal squamous cell carcinoma-1; DLL3: delta-like ligand 3; BC: breast cancer; OS: osteosarcoma; EWS: Ewing’s sarcoma; MEL: melanoma; VEGFR-2: vascular endothelial growth factor receptor 2; RCC: renal cell carcinoma; CAIX: carbonic anhydrase IX; GPC3: glypican-3; OC: ovarian cancer; CC: cervical cancer; ALPPL2: alkaline phosphatase placental-like 2; PCa: prostate cancer; PSMA: prostate-specific membrane antigen; PSCA: prostate stem cell antigen; CRC: colorectal cancer; PC: pancreatic cancer; CLDN: claudin; GC: gastric cancer; GUCY2C: Guanylyl cyclase C; HCC: hepatocellular carcinoma; EC: esophageal cancer