Table 3.

Multispecific CAR-T cell therapy in solid tumors

Condition	Targeting domain	Reference
HCC	CD70/B7H3	[189, 414, 432–434]
	GPC3/CD147
	c-MET/PD-L1
	GPC3/ASGR1 gp100/HER2
Glioma	CD70/B7H3	[189, 374–376, 435, 436]
	HER2/IL13Rα2
	EGFRvIII/IL13Rα2 OR EphA2; MOG/IL13Rα2 OR EphA2
	EGFRvIII/IL13Rα2 OR CD133
	HER2/IL13Rα2/EphA2
	IL13Rα2/ EphA2
GC	Trop2/PD-L1	[277]
PC	MSLN/CEA	[437, 438]
	MSLN/PSMA
EC	CD70/B7H3	[189]
CRC	CD30/CEA; CD30/TAG70	[439]
BC	CD70/B7H3	[189, 414, 440–442]
	Her2/IGF1R
	MUC1/HER2
	ROR1/B7H3 gp100/HER2
PCa	MSLN/PSMA	[437]
LCa	CD70/B7H3	[189, 204, 442]
	ROR1/B7H3 PSCA/MUC1
OC	FLOR1/MSLN	[330, 333, 334]
	ALPPL2/MCAM ALPPL2/MSLN ALPPL2/HER2 PD-L1/MUC16
MEL	CD70/B7H3 gp100/CSPG4 gp100/VEGFR-2	[189, 314, 443]