Figure 2:

NKG2D expression drives disease severity. (a) Kaplan–Meier survival analysis of Apc^min/+;Klrk1^+/+ (n = 40) and Apc^min/+;Klrk1^−/− (n = 35) mice. (b) Correlation between number of small intestinal (SI) tumors and survival in Apc^min/+;Klrk1^+/+ (top, red) and Apc^min/+;Klrk1^−/− (bottom, blue) mice. (c) Number of tumors in the colon of Apc^min/+;Klrk1^+/+ (n = 40) and Apc^min/+;Klrk1^−/− mice (n = 35) at disease endpoint. (d) Hematocrit (HCT) measures from the blood of healthy Klrk1^+/+ control mice (n = 8), Apc^min/+;Klrk1^+/+ (n = 18) and Apc^min/+;Klrk1^−/− (n = 15) mice at disease endpoint. Data points represent individual mice. SI: small intestine; HCT: hematocrit. Significance was determined using log-rank (Mantel–Cox) test (a), linear regression (b), Mann–Whitney U or unpaired t-test following Shapiro–Wilk normality test (c) and one-way analysis of variance (ANOVA) and Tukey’s multiple comparison test (d). *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, and ****P ≤ 0.0001.